Identification and disruption of the proBA locus in Listeria monocytogenes: role of proline biosynthesis in salt tolerance and murine infection.

@article{Sleator2001IdentificationAD,
  title={Identification and disruption of the proBA locus in Listeria monocytogenes: role of proline biosynthesis in salt tolerance and murine infection.},
  author={Roy D Sleator and Cormac G M Gahan and Colin Hill},
  journal={Applied and environmental microbiology},
  year={2001},
  volume={67 6},
  pages={
          2571-7
        }
}
Intracellular accumulation of the amino acid proline has previously been linked to the salt tolerance and virulence potential of a number of bacteria. Taking advantage of the proBA mutant Escherichia coli CSH26, we identified a listerial proBA operon coding for enzymes functionally similar to the glutamyl kinase (GK) and glutamylphosphate reductase (GPR) enzyme complex which catalyzes the first and second steps of proline biosynthesis in E. coli. The first gene of the operon, proB, is predicted… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 41 CITATIONS

The response of foodborne pathogens to osmotic and desiccation stresses in the food chain.

  • International journal of food microbiology
  • 2016
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 57 REFERENCES

Stress response in pathogenic bacteria

VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Analysis of the role of betL in contributing to the growth and survival of Listeria monocytogenes LO28

R. D. Sleator, C.G.M. Gahan, B. O’Driscoll, C. Hill
  • Int. J. Food Microbiol
  • 2000