Identification and directed biosynthesis of efrapeptins in the fungusTolypocladium geodes gams (Deuteromycotina: Hyphomycetes)

  title={Identification and directed biosynthesis of efrapeptins in the fungusTolypocladium geodes gams (Deuteromycotina: Hyphomycetes)},
  author={Stuart B Krasnoff and Sandeep K Gupta},
  journal={Journal of Chemical Ecology},
HPLC analysis of crude dichloromethane extracts of shaken liquid cultures of the hyphomycetous fungusTolypocladium geodes Gams revealed the presence of efrapeptins. These peptides, which have mitochondrial ATPase inhibitory activity as well as antifungal and insecticidal properties, are previously known only from the congeneric species,T. niveum Rostrup. The identity of efrapeptins was confirmed by fast atom bombardment mass spectrometry and by amino acid analysis. HPLC analyses of efrapeptins… 
Efrapeptin production byTolypocladium fungi (Deuteromycotina: Hyphomycetes): Intra- and interspecific variation
Production of the mitochondrial ATPase inhibitory peptides efrapeptins was evaluated by HPLC analysis in 44 strains of nine species of the fungal genusTolypocladium and Efrapeptin identification was confirmed by mass spectral data for the first time in the speciesT.
Sequences of Tolypins, Insecticidal Efrapeptin‐Type Peptaibiotics from Species of the Fungal Genus Tolypocladium
Close relationship and partial identity of sequences of tolypins and efrapeptins, which had previously been postulated, were definitely proven.
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To introduce fungal species hitherto unknown as producers of peptaibiotics, the relevant literature is reviewed and ecophysiological and taxonomic aspects of the producing fungi are discussed.
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Owing to the ubiquity and biodiversity of the fungal producers in the biosphere, the discovery of a myriad of peptaibiotics within the next decade is predicted.
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Structure of Efrapeptins From the Fungus Tolypocladium Niveum: Peptide Inhibitors of Mitochondrial ATPase
Efrapeptins, a group of peptide toxins, were isolated from the culture filtrates of the fungus Tolypocladium niveum and complete stereostructures of five efrapeptins C-G were established. The
Production of xanthomegnin and viomellein by isolates of Aspergillus ochraceus, Penicillium cyclopium, and Penicillium viridicatum
Fungal isolates from legumes were cultured on rice and examined for production of the toxic mold metabolites xanthomegnin and viomellein and this is the first report of xanthomeric mold metabolites production by A. ochraeus and P. cyclopium.
Notes on Tolypocladium and related genera
The hyphomycete genus Tolypocladium W. Gams is compared with similar genera possessing swollen phialides and amerosporous conidia borne in slimy heads, and two new species of TolyPocladium are described from tundra soils.
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The cyclosporin A and C exhibit a narrow spectrum of antifungal activity and in addition have immunosuppressive properties.
The peptide antibiotics of Bacillus: chemistry, biogenesis, and possible functions.
The present study focuses on the development of anti-inflammatory drugs in the context of the industrial revolution and the role of pharmaceuticals in this process.
Directed biosynthesis of Cyclosporins
  • H. Kobel, R. Traber
  • Biology
    European journal of applied microbiology and biotechnology
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SummaryThe Cyclosporins A, B, C, D and G are cyclic undecapeptides produced by the fungus Tolypocladium inflatum Gams which vary in the amino acid they contain at position 2. The amount of production
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