Identification and developmental expression analysis of a novel homeobox gene closely linked to the mouse Twirler mutation.

@article{Liu2006IdentificationAD,
  title={Identification and developmental expression analysis of a novel homeobox gene closely linked to the mouse Twirler mutation.},
  author={Han Liu and Wenjin Liu and Kathleen M. Maltby and Yu Lan and Rulang Jiang},
  journal={Gene expression patterns : GEP},
  year={2006},
  volume={6 6},
  pages={632-6}
}
The Twirler mutation arose spontaneously and causes inner ear defects in heterozygous and cleft lip and/or cleft palate in homozygous mutant mice, providing a unique animal model for investigating the molecular mechanisms of inner ear and craniofacial development. Here, we report the identification of a novel homeobox gene, Iroquois-related homeobox like-1 (Irxl1), from the Twirler locus. Irxl1 encodes a TALE-family homeodomain protein with its homeodomain exhibiting the highest amino acid… CONTINUE READING

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