Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers.

@article{Albiston2011IdentificationAD,
  title={Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers.},
  author={Anthony Lloyd Albiston and Shanti Diwakarla and Ruani N Fernando and S. Joy Mountford and Holly R. Yeatman and Broden Morgan and Vi Pham and Jessica K Holien and Michael W Parker and Philip E. Thompson and S. Y. Chai},
  journal={British journal of pharmacology},
  year={2011},
  volume={164 1},
  pages={37-47}
}
Two structurally distinct peptides, angiotensin IV and LVV-haemorphin 7, both competitive high-affinity inhibitors of insulin-regulated aminopeptidase (IRAP), were found to enhance aversion-associated and spatial memory in normal rats and to improve performance in a number of memory tasks in rat deficits models. These findings provide compelling support for the development of specific, high-affinity inhibitors of the enzyme as new cognitive enhancing agents. Different classes of IRAP inhibitors… CONTINUE READING

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