Identification and determination of the S-methyl metabolite of captopril in human plasma by selected-ion monitoring gas chromatography-mass spectrometry.

@article{Cohen1984IdentificationAD,
  title={Identification and determination of the S-methyl metabolite of captopril in human plasma by selected-ion monitoring gas chromatography-mass spectrometry.},
  author={A. Cohen and E. Ivashkiv and T. McCormick and D. Mckinstry},
  journal={Journal of pharmaceutical sciences},
  year={1984},
  volume={73 10},
  pages={
          1493-5
        }
}
  • A. Cohen, E. Ivashkiv, +1 author D. Mckinstry
  • Published 1984
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • The S-methyl metabolite of captopril was identified and determined in human plasma by positive chemical ionization selected-ion monitoring gas chromatography-mass spectrometry. After oral administration of 100 mg of captopril to healthy subjects, the maximum plasma level was 60-114 ng/mL. These data for the S-methyl metabolite of captopril were correlated to total and unchanged captopril levels. Captopril--identification and determination of the S-methyl metabolite in human plasma, gas… CONTINUE READING
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    The disposition and metabolism of captopril
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    • Journal of pharmaceutical sciences
    • 1984
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