Identification and determination of 2-thiothiazolidine-4-carboxylic acid in urine of workers exposed to carbon disulfide

@article{Doorn1981IdentificationAD,
  title={Identification and determination of 2-thiothiazolidine-4-carboxylic acid in urine of workers exposed to carbon disulfide},
  author={R. van Doorn and L. P. C. P. Delbressine and Ch. -M. Leijdekkers and P. G. Vertin and Paul T Henderson},
  journal={Archives of Toxicology},
  year={1981},
  volume={47},
  pages={51-58}
}
A compound was isolated from the urine of workers exposed to carbon disulfide during the production of rayon. The compound was identified as 2-thiothiazolidine-4-carboxylic acid (TTCA) by GC/MS and NMR. A HPLC method for the quantitative determination of TTCA was elaborated and applied to urine samples. The method allowed detection of TTCA concentrations in urine as low as 5 × 10−7 M. No TTCA was detected in urine of workers occupationally exposed to organic solvents other than CS2. High… CONTINUE READING
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