Identification and comparative expression analysis of a second wt1 gene in zebrafish.

@article{Bollig2006IdentificationAC,
  title={Identification and comparative expression analysis of a second wt1 gene in zebrafish.},
  author={Frank Bollig and Rebecca Mehringer and Birgit Perner and Christina Hartung and Matthias Sch{\"a}fer and Manfred Schartl and Jean-Nicolas Volff and Christoph Winkler and Christoph Englert},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2006},
  volume={235 2},
  pages={554-61}
}
The Wilms' tumor suppressor gene wt1 encodes a zinc-finger transcription factor that plays an important role in the development of the mammalian genitourinary system. Mutations in WT1 in humans lead to anomalies of kidney and gonad development and cause Wilms' tumor, a pediatric kidney cancer. The inactivation of both wt1 alleles in mice gives rise to multiple organ defects, among them agenesis of kidney, spleen, and gonads. In zebrafish, an ortholog of wt1 has been described that is expressed… CONTINUE READING