Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon.

@article{Li2000IdentificationAC,
  title={Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon.},
  author={Yan A. Li and Zachary F Pursell and S. Linn},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 30},
  pages={23247-52}
}
HeLa DNA polymerase epsilon (pol epsilon), possibly involved in both DNA replication and DNA repair, was previously isolated as a complex of a 261-kDa catalytic subunit and a tightly bound 59-kDa accessory protein. Saccharomyces cerevisiae pol epsilon, however, consists of four subunits: a 256-kDa catalytic subunit with 39% identity to HeLa pol epsilon p261, a 80-kDa subunit (DPB2) with 26% identity to HeLa pol epsilon p59, a 23-kDa subunit (DPB3), and a 22-kDa subunit (DPB4). We report here… CONTINUE READING

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