Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box.

@article{Wetering1991IdentificationAC,
  title={Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box.},
  author={Marc van de Wetering and Mari{\"e}tte Oosterwegel and Dennis Dooijes and Hans Clevers},
  journal={The EMBO journal},
  year={1991},
  volume={10 1},
  pages={
          123-32
        }
}
CD3-epsilon expression is controlled by a downstream T lymphocyte-specific enhancer element. We report the identification of a T cell-specific transcription factor, TCF-1, binding to this element. The multimerized recognition motif of TCF-1 constituted a T cell-specific enhancer. Subsequent cloning of TCF-1 identified three splice alternatives. TCF-1 contained a single DNA-binding HMG box most closely related to similar boxes in the putative mammalian sex-determining gene SRY and in the… CONTINUE READING
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