Identification and classification of differentially expressed genes in renal cell carcinoma by expression profiling on a global human 31,500-element cDNA array.

@article{Boer2001IdentificationAC,
  title={Identification and classification of differentially expressed genes in renal cell carcinoma by expression profiling on a global human 31,500-element cDNA array.},
  author={J. M. Boer and Willi Huber and Holger S{\"u}ltmann and F. Wilmer and Anja von Heydebreck and Stephan Haas and Bernhard Korn and Bastian Gunawan and Andreas Vente and L{\'a}szl{\'o} F{\"u}zesi and Martin Vingron and Annemarie Poustka},
  journal={Genome research},
  year={2001},
  volume={11 11},
  pages={1861-70}
}
We investigated the changes in gene expression accompanying the development and progression of kidney cancer by use of 31,500-element complementary DNA arrays. We measured expression profiles for paired neoplastic and noncancerous renal epithelium samples from 37 individuals. Using an experimental design optimized for factoring out technological and biological noise, and an adapted statistical test, we found 1738 differentially expressed cDNAs with an expected number of six false positives… CONTINUE READING

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