Identification and characterization of up-regulated genes during chondrocyte hypertrophy.

  title={Identification and characterization of up-regulated genes during chondrocyte hypertrophy.},
  author={Maria V. Nurminskaya and Thomas F. Linsenmayer},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  volume={206 3},
Chondrocyte hypertrophy involves de novo acquisition and/or increased expression of certain gene products including, among others, type X collagen, alkaline phosphatase, and matrix metalloproteinases. To analyze further the genetic program associated with chondrocyte hypertrophy, we have employed a modification of the polymerase chain reaction-mediated subtractive hybridization method of Wang and Brown (Wang and Brown [1991] Proc. Natl. Acad. Sci 88:11505). Cultures of hypertrophic tibial… CONTINUE READING


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