Identification and characterization of two nonessential regions of the rabbitpox virus genome involved in virulence.

@article{Bloom1991IdentificationAC,
  title={Identification and characterization of two nonessential regions of the rabbitpox virus genome involved in virulence.},
  author={David C. Bloom and Kirsten M. Edwards and Casey Hager and Richard W. Moyer},
  journal={Journal of virology},
  year={1991},
  volume={65 3},
  pages={1530-42}
}
We have developed a means to identify genes associated with particular aspects of virulence. By beginning with an avirulent deletion mutant of rabbitpox virus and systematically reintroducing overlapping segments of the deleted region, we have identified two regions of the viral genome associated with increased virulence in mice. Evaluation of illness has been aided by the exploitation of weight loss as an indicator of pathogenesis. One of the regions identified by this method contains several… CONTINUE READING

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