Identification and characterization of the viral interaction determinant of the subgroup A avian leukosis virus receptor.

@article{Zingler1995IdentificationAC,
  title={Identification and characterization of the viral interaction determinant of the subgroup A avian leukosis virus receptor.},
  author={Kurt Zingler and Claire B{\'e}langer and Rowayda Peters and E A Agard and John A. T. Young},
  journal={Journal of virology},
  year={1995},
  volume={69 7},
  pages={4261-6}
}
The cellular receptor for subgroup A avian leukosis viruses (ALV-A) has a small, 83-amino-acid extracellular domain containing a motif that is related in sequence to the ligand binding repeats of the low-density lipoprotein receptor. Extensive mutagenesis of the ALV-A receptor has identified two acidic amino acids (Asp-46 and Glu-47) and an adjacent aromatic amino acid (Trp-48) in the carboxy-terminal portion of this low-density lipoprotein receptor-related motif that are crucial for efficient… CONTINUE READING