Identification and characterization of the slowly exchanging pH-dependent conformational rearrangement in KcsA.

@article{Takeuchi2007IdentificationAC,
  title={Identification and characterization of the slowly exchanging pH-dependent conformational rearrangement in KcsA.},
  author={Koh Takeuchi and Hideo Takahashi and Seiko Kawano and Ichio Shimada},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 20},
  pages={
          15179-86
        }
}
  • Koh Takeuchi, Hideo Takahashi, +1 author Ichio Shimada
  • Published in
    The Journal of biological…
    2007
  • Chemistry, Medicine
  • Gating of ion channels is strictly regulated by physiological conditions as well as intra/extracellular ligands. To understand the underlying structures mediating ion channel gating, we investigated the pH-dependent gating of the K(+) channel KcsA under near-physiological conditions, using solution-state NMR. In a series of (1)H(15)N-TROSY HSQC (transverse relaxation optimized spectroscopy-heteronuclear single quantum coherence) spectra measured at various pH values, significant chemical shift… CONTINUE READING

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