Identification and characterization of the role of c-terminal Src kinase in dengue virus replication

@inproceedings{Kumar2016IdentificationAC,
  title={Identification and characterization of the role of c-terminal Src kinase in dengue virus replication},
  author={Rajeev Kumar and Tanvi Agrawal and Naseem Ahmed Khan and Yuji Nakayama and Guruprasad R Medigeshi},
  booktitle={Scientific reports},
  year={2016}
}
We screened a siRNA library targeting human tyrosine kinases in Huh-7 cells and identified c-terminal Src kinase (Csk) as one of the kinases involved in dengue virus replication. Knock-down of Csk expression by siRNAs or inhibition of Csk by an inhibitor reduced dengue virus RNA levels but did not affect viral entry. Csk partially colocalized with viral replication compartments. Dengue infection was drastically reduced in cells lacking the three ubiquitous src family kinases, Src, Fyn and Yes… CONTINUE READING
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