Identification and characterization of the neutralization epitope(s) of the hepatitis E virus.

@article{Meng2001IdentificationAC,
  title={Identification and characterization of the neutralization epitope(s) of the hepatitis E virus.},
  author={Ji-hong Meng and Xing Dai and Jinq Chyi Chang and Elena N Lopareva and Jacques Pillot and Howard A Fields and Y. Khudyakov},
  journal={Virology},
  year={2001},
  volume={288 2},
  pages={203-11}
}
The neutralization epitope(s) of the hepatitis E virus (HEV) was studied by an in vitro neutralization assay using antibodies obtained by immunization of mice with 51 overlapping 30-mer synthetic peptides spanning the region 221-660 amino acids (aa) of the HEV open reading frame 2 encoded protein (pORF2) and 31 overlapping recombinant proteins of different sizes derived from the entire pORF2 of the HEV Burma strain. Antibodies against synthetic peptides and short recombinant proteins of… CONTINUE READING