Identification and characterization of the integrin alpha2beta1 binding motif in chondroadherin mediating cell attachment.

@article{Haglund2011IdentificationAC,
  title={Identification and characterization of the integrin alpha2beta1 binding motif in chondroadherin mediating cell attachment.},
  author={Lisbet Haglund and Viveka Tillgren and Laura Addis and Christina Wengl{\'e}n and Anneliese D. Recklies and Dick Heineg{\aa}rd},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 5},
  pages={3925-34}
}
Chondroadherin is a leucine-rich repeat protein known to mediate adhesion of isolated cells via the integrin α(2)β(1) and to interact with collagen. In this work, we show that cell adhesion to chondroadherin leads to activation of MAPKs but does not result in cell spreading and division. This is in contrast to the spreading and dividing of cells grown on collagen, although the binding is mediated via the same α(2)β(1) receptor. We identified a cell binding motif, CQLRGLRRWLEAK(318) by mass… CONTINUE READING

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