Identification and characterization of the genetic changes responsible for the characteristic smooth-to-rough morphotype alterations of clinically persistent Mycobacterium abscessus.

@article{Pawlik2013IdentificationAC,
  title={Identification and characterization of the genetic changes responsible for the characteristic smooth-to-rough morphotype alterations of clinically persistent Mycobacterium abscessus.},
  author={Alexandre Pawlik and Guillaume Garnier and Mickael Orgeur and Pin Tong and Amanda J. Lohan and Fabien le Chevalier and Guillaume Sapriel and A L Roux and Kevin Conlon and Nadine Honor{\'e} and Marie-Agn{\`e}s Dillies and Laurence Ma and Christiane Bouchier and Jean-Yves Copp{\'e}e and J. -L. Gaillard and Stephen V. Gordon and Brendan Loftus and Roland Brosch and Jean Louis Herrmann},
  journal={Molecular microbiology},
  year={2013},
  volume={90 3},
  pages={612-29}
}
Mycobacterium abscessus is an emerging pathogen that is increasingly recognized as a relevant cause of human lung infection in cystic fibrosis patients. This highly antibiotic-resistant mycobacterium is an exception within the rapidly growing mycobacteria, which are mainly saprophytic and non-pathogenic organisms. M. abscessus manifests as either a smooth (S) or a rough (R) colony morphotype, which is of clinical importance as R morphotypes are associated with more severe and persistent… CONTINUE READING
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