Identification and characterization of the first cholesterol-dependent cytolysins from Gram-negative bacteria.


The cholesterol-dependent cytolysins (CDCs) are pore-forming toxins that have been exclusively associated with a wide variety of bacterial pathogens and opportunistic pathogens from the Firmicutes and Actinobacteria, which exhibit a Gram-positive type of cell structure. We have characterized the first CDCs from Gram-negative bacterial species, which include… (More)
DOI: 10.1128/IAI.00927-12