Identification and characterization of the hypoxia-responsive element of the human placental 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene.

@article{Fukasawa2004IdentificationAC,
  title={Identification and characterization of the hypoxia-responsive element of the human placental 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene.},
  author={Masashi Fukasawa and Terumasa Tsuchiya and Eiji Takayama and Nariyoshi Shinomiya and K. M. Uyeda and Ryuzo Sakakibara and Shuhji Seki},
  journal={Journal of biochemistry},
  year={2004},
  volume={136 3},
  pages={273-7}
}
The placenta-type isozyme of human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (HP2K, identical to PFKFB3) is expressed in a variety of cells and tissues such as placenta, brain, testis, liver, kidney, skeletal muscle, primary blood mononuclear cells and cancer cells. We observed previously that the enhancer region of the HP2K gene, which has been identified in the 5'-flanking region between -1265 and -1329, could respond to serum stimulation following the transfection of human… CONTINUE READING
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