Corpus ID: 23786252

Identification and characterization of the canine multidrug resistance-associated protein.

  title={Identification and characterization of the canine multidrug resistance-associated protein.},
  author={Liandong Ma and S. Pratt and J. Cao and A. Dantzig and R. Moore and C. Slapak},
  journal={Molecular cancer therapeutics},
  volume={1 14},
  • Liandong Ma, S. Pratt, +3 authors C. Slapak
  • Published 2002
  • Biology, Medicine
  • Molecular cancer therapeutics
  • Human multidrug resistance protein 1 (MRP1) confers resistance to the Vinca alkaloids, the anthracyclines, and the epipodophyllotoxins. It is also capable of binding to and transporting the glutathione S-conjugate leukotriene C4 (LTC4) in isolated membrane vesicles. To explore species differences that exist between MRP orthologs, we cloned and characterized the mRNA encoding a canine ortholog of human MRP1-designated canine MRP1 (canMRP1). The canMRP1 mRNA encodes a protein of identical length… CONTINUE READING
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