Identification and characterization of the binding sites of P-glycoprotein for multidrug resistance-related drugs and modulators.

@article{Safa2004IdentificationAC,
  title={Identification and characterization of the binding sites of P-glycoprotein for multidrug resistance-related drugs and modulators.},
  author={Ahmad R. Safa},
  journal={Current medicinal chemistry. Anti-cancer agents},
  year={2004},
  volume={4 1},
  pages={1-17}
}
  • Ahmad R. Safa
  • Published 2004 in Current medicinal chemistry. Anti-cancer agents
A major problem in cancer treatment is the development of resistance to multiple chemotherapeutic agents in tumor cells. A major mechanism of this multidrug resistance (MDR) is overexpression of the MDR1 product P-glycoprotein, known to bind to and transport a wide variety of agents. This review concentrates on the progress made toward understanding the role of this protein in MDR, identifying and characterizing the drug binding sites of P-glycoprotein, and modulating MDR by P-glycoprotein… CONTINUE READING

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