Identification and characterization of the afsR homologue regulatory gene from Streptomyces peucetius ATCC 27952.

@article{Parajuli2005IdentificationAC,
  title={Identification and characterization of the afsR homologue regulatory gene from Streptomyces peucetius ATCC 27952.},
  author={Niranjan Parajuli and Hung Trinh Viet and Kenji Ishida and Hang Tong and Hei Chan Lee and Kwangkyoung Liou and Jae Kyung Sohng},
  journal={Research in microbiology},
  year={2005},
  volume={156 5-6},
  pages={707-12}
}
We have isolated an afsR homologue, called afsR-p, through genome analysis of Streptomyces peucetius ATCC 27952. AfsR-p shares 60% sequence identity with AfsR from Streptomyces coelicolor A3 (2). afsR-p was expressed under the control of the ermE* promoter in its hosts S. peucetius, Streptomyces lividans TK 24, Streptomyces clavuligerus and Streptomyces griseus. We observed overproduction of doxorubicin (4-fold) in S. peucetius, gamma-actinorhodin (2.6-fold) in S. lividans, clavulanic acid (1.5… CONTINUE READING

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