Identification and characterization of the PutP proline permease that contributes to in vivo survival of Staphylococcus aureus in animal models.

@article{Schwan1998IdentificationAC,
  title={Identification and characterization of the PutP proline permease that contributes to in vivo survival of Staphylococcus aureus in animal models.},
  author={William R Schwan and Silvija N. Coulter and Eva Y. W. Ng and Michael H. Langhorne and Heather D. Ritchie and Linnea L. Brody and S. Westbrock-Wadman and Arnold S. Bayer and Kim R. Folger and C. Kendal Stover},
  journal={Infection and immunity},
  year={1998},
  volume={66 2},
  pages={567-72}
}
Staphylococcus aureus is an important pathogen of humans and other animals, causing bacteremia, abscesses, endocarditis, and other infectious syndromes. A signature-tagged mutagenesis (STM) system was adapted for use in studying the genes required for in vivo survival of S. aureus. An STM library was ultimately created in S. aureus RN6390, with Tn917 being used to create the transposon mutations. Pools of S. aureus RN6390 mutants were screened in mouse abscess, bacteremia, and wound infection… CONTINUE READING