Identification and characterization of the vesicular GABA transporter

@article{McIntire1997IdentificationAC,
  title={Identification and characterization of the vesicular GABA transporter},
  author={Steven L. McIntire and Richard J. Reimer and Kim Schuske and Robert H Edwards and Erik M. Jorgensen},
  journal={Nature},
  year={1997},
  volume={389},
  pages={870-876}
}
Synaptic transmission involves the regulated exocytosis of vesicles filled with neurotransmitter. Classical transmitters are synthesized in the cytoplasm, and so must be transported into synaptic vesicles. Although the vesicular transporters for monoamines and acetylcholine have been identified, the proteins responsible for packaging the primary inhibitory and excitatory transmitters, γ-aminobutyric acid (GABA) and glutamate remain unknown,. Studies in the nematode Caenorhabditis elegans have… CONTINUE READING
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