Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor.

@article{Shao2003IdentificationAC,
  title={Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor.},
  author={Huang Shao and Haiyun Y. Cheng and Richard G. Cook and David J Tweardy},
  journal={Cancer research},
  year={2003},
  volume={63 14},
  pages={3923-30}
}
The oncogene signal transducer and activator of transcription 3 (Stat3) is constitutively activated in a wide variety of human cancers, including squamous cell carcinoma of the head and neck. In squamous cell carcinoma of the head and neck, Stat3 activation is mediated by up-regulation of the autocrine ligand-receptor pair, tumor growth factor alpha and epidermal growth factor receptor (EGFR), resulting in cell growth and resistance to apoptosis. The initiating molecular event in Stat3… CONTINUE READING
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