Identification and characterization of retinoid-active short-chain dehydrogenases/reductases in Drosophila melanogaster.

@article{Belyaeva2009IdentificationAC,
  title={Identification and characterization of retinoid-active short-chain dehydrogenases/reductases in Drosophila melanogaster.},
  author={Olga Belyaeva and S W Lee and Oleg V Kolupaev and Natalia Y Kedishvili},
  journal={Biochimica et biophysica acta},
  year={2009},
  volume={1790 10},
  pages={1266-73}
}
BACKGROUND In chordates, retinoid metabolism is an important target of short-chain dehydrogenases/reductases (SDRs). It is not known whether SDRs play a role in retinoid metabolism of protostomes, such as Drosophila melanogaster. METHODS Drosophila genome was searched for genes encoding proteins with approximately 50% identity to human retinol dehydrogenase 12 (RDH12). The corresponding proteins were expressed in Sf9 cells and biochemically characterized. Their phylogenetic relationships were… CONTINUE READING
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