Identification and characterization of 1,25-dihydroxyvitamin D3-responsive repressor sequences in the rat parathyroid hormone-related peptide gene.

@article{Kremer1996IdentificationAC,
  title={Identification and characterization of 1,25-dihydroxyvitamin D3-responsive repressor sequences in the rat parathyroid hormone-related peptide gene.},
  author={Richard Kremer and Michael Sebag and C{\'e}line Champigny and Karen Meerovitch and Geoffrey N Hendy and John White and David Goltzman},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 27},
  pages={16310-6}
}
Parathyroid hormone-related peptide (PTHRP) gene transcription is suppressed by 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the active metabolite of vitamin D3. In the present report, we examined 1, 25(OH)2D3-mediated repression of PTHRP expression by transfection of PTHRP promoter/reporter constructs in normal human keratinocytes and by DNA binding. We localized an element conferring 1, 25(OH)2D3-mediated repression in vivo to a 47-base pair (bp) region located -1121 to -1075 from the… CONTINUE READING

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