Identification and characterization of pathogenetically relevant genes in mature aggressive B-cell lymphomas of childhood by a combination of genomic and functional analyses

@inproceedings{Wagener2015IdentificationAC,
  title={Identification and characterization of pathogenetically relevant genes in mature aggressive B-cell lymphomas of childhood by a combination of genomic and functional analyses},
  author={Rabea Wagener},
  year={2015}
}
Burkitt lymphomas (BL) account for about 25 % of the mature B-cell lymphomas in childhood. The hallmark of BL is the chromosomal translocation t(8;14)(q24;q32), juxtaposing the MYC gene to the immunoglobulin (IG) heavy chain locus, or one of its light chain variants. These translocations result in overexpression of the oncogenic transcription factor MYC. However, the IG-MYC translocation alone is not sufficient to drive lymphomagenesis. Additional alterations are necessary for malignant… CONTINUE READING

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