Identification and characterization of ErbB-3-binding protein-1 as a target for immunotherapy.

@article{Santegoets2007IdentificationAC,
  title={Identification and characterization of ErbB-3-binding protein-1 as a target for immunotherapy.},
  author={Saskia J. A. M. Santegoets and Marco W J Schreurs and Anneke W. Reurs and Jelle J. Lindenberg and Esther W. M. Kueter and Alfons J. M. van den Eertwegh and Erik Hooijberg and Ricardo J M G E Brandwijk and Simon E. Hufton and Hennie R. Hoogenboom and Rik J. Scheper and Veerle A. Somers and Tanja D. de Gruijl},
  journal={Journal of immunology},
  year={2007},
  volume={179 3},
  pages={2005-12}
}
Based on immune reactivity in response to a whole-cell colon tumor vaccine and using serological identification of Ags by recombinant cDNA expression cloning, we here describe the molecular and functional identification of a novel human tumor Ag. By screening a cDNA expression library derived from the coloncarcinoma cell line HT-29 with pooled colorectal cancer patients' sera, 26 clones reactive with IgG Abs could be identified. Characterization of these cDNA clones by sequence analysis and… CONTINUE READING