Identification and characterization of hemoangiogenic progenitors during cynomolgus monkey embryonic stem cell differentiation.

@article{Umeda2006IdentificationAC,
  title={Identification and characterization of hemoangiogenic progenitors during cynomolgus monkey embryonic stem cell differentiation.},
  author={Katsutsugu Umeda and Toshio Heike and Momoko Yoshimoto and Gen Shinoda and Mitsutaka Shiota and Hirofumi Suemori and H. Y. Luo and David H. K. Chui and Ryuzo Torii and Masabumi Shibuya and Norio Nakatsuji and Tatsutoshi Nakahata},
  journal={Stem cells},
  year={2006},
  volume={24 5},
  pages={1348-58}
}
We identified intermediate-stage progenitor cells that have the potential to differentiate into hematopoietic and endothelial lineages from nonhuman primate embryonic stem (ES) cells. Sequential fluorescence-activated cell sorting and immunostaining analyses showed that when ES cells were cultured in an OP9 coculture system, both lineages developed after the emergence of two hemoangiogenic progenitor-bearing cell fractions, namely, vascular endothelial growth factor receptor (VEGFR)-2(high… CONTINUE READING

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