Identification and characterization of nucleolin as a c-myc G-quadruplex-binding protein.

@article{Gonzalez2009IdentificationAC,
  title={Identification and characterization of nucleolin as a c-myc G-quadruplex-binding protein.},
  author={Veronica Gonzalez and Kexiao Guo and Laurence H Hurley and Daekyu Sun},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 35},
  pages={23622-35}
}
myc is a proto-oncogene that plays an important role in the promotion of cellular growth and proliferation. Understanding the regulation of c-myc is important in cancer biology, as it is overexpressed in a wide variety of human cancers, including most gynecological, breast, and colon cancers. We previously demonstrated that a guanine-rich region upstream of the P1 promoter of c-myc that controls 85-90% of the transcriptional activation of this gene can form an intramolecular G-quadruplex (G4… CONTINUE READING