Identification and characterization of nuclear factor kappaB binding sites in the murine bcl-x promoter.

@article{Glasgow2000IdentificationAC,
  title={Identification and characterization of nuclear factor kappaB binding sites in the murine bcl-x promoter.},
  author={Joel N. Glasgow and Thomas Wood and J. Regino Perez-polo},
  journal={Journal of neurochemistry},
  year={2000},
  volume={75 4},
  pages={
          1377-89
        }
}
Signal transduction pathways that mediate neuronal commitment to apoptosis involve the nuclear factor kappaB (NF-kappaB) transcription factor. Bcl-X(L) is a potent regulator of apoptosis in the CNS and is highly expressed in the developing and adult brain. We identified three putative NF-kappaB DNA binding sequences clustered upstream of the brain-specific transcription start site in the upstream promoter region. Recombinant p50/p50 and NF-kappaB proteins from nuclear extracts bound to these… CONTINUE READING

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