Identification and characterization of novel sodium channel toxins from the sea anemone Anthopleura xanthogrammica.

@article{Kelso1998IdentificationAC,
  title={Identification and characterization of novel sodium channel toxins from the sea anemone Anthopleura xanthogrammica.},
  author={G J Kelso and Kenneth M. Blumenthal},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={1998},
  volume={36 1},
  pages={41-51}
}
Six new toxins from the sea anemone Anthopleura xanthogrammica were identified using a molecular biological approach. Five of these novel isoforms resemble the 47 residue type I long polypeptides native to Anthopleura elegantissima, Anthopleura fuscoviridis and Anemonia sulcata, while one appears to be chimera of the two previously identified 49 residue toxins native to A. xanthogrammica. Four of these toxins were expressed in bacteria, purified and characterized by ion flux assays in RT4-B and… CONTINUE READING