Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk.

@article{Lin2015IdentificationAC,
  title={Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk.},
  author={Wei-Yu Lin and N. Camp and M. Ghoussaini and J. Beesley and K. Michailidou and J. Hopper and C. Apicella and M. Southey and J. Stone and M. Schmidt and A. Broeks and L. V. van't Veer and E. J. Th. Rutgers and K. Muir and A. Lophatananon and S. Stewart-Brown and P. Siriwanarangsan and P. Fasching and L. Haeberle and A. Ekici and M. Beckmann and J. Peto and I. Dos-Santos-Silva and O. Fletcher and N. Johnson and M. K. Bolla and Q. Wang and J. Dennis and E. Sawyer and Timothy H T Cheng and I. Tomlinson and M. Kerin and N. Miller and F. Marme and H. Surowy and B. Burwinkel and P. Gu{\'e}nel and T. Truong and F. Menegaux and Claire Mulot and S. Bojesen and B. Nordestgaard and S. F. Nielsen and H. Flyger and J. Ben{\'i}tez and M. Zamora and J. A. Arias P{\'e}rez and P. Men{\'e}ndez and A. Gonz{\'a}lez-Neira and G. Pita and M. R. Alonso and N. Alvarez and D. Herrero and H. Anton-Culver and H. Brenner and A. K. Dieffenbach and V. Arndt and C. Stegmaier and A. Meindl and P. Lichtner and R. Schmutzler and B. M{\"u}ller-Myhsok and H. Brauch and T. Br{\"u}ning and Yon‐Dschun Ko and D. Tessier and Daniel Vincent and F. Bacot and H. Nevanlinna and K. Aittom{\"a}ki and C. Blomqvist and S. Khan and K. Matsuo and H. Ito and H. Iwata and Akiyo Horio and N. Bogdanova and N. Antonenkova and T. D{\"o}rk and A. Lindblom and S. Margolin and A. Mannermaa and V. Kataja and V. Kosma and J. Hartikainen and A. Wu and Chiu-chen Tseng and D. J. van den Berg and D. Stram and P. Neven and E. Wauters and H. Wildiers and D. Lambrechts and J. Chang-Claude and A. Rudolph and P. Seibold and D. Flesch‐Janys and P. Radice and P. Peterlongo and S. Manoukian and B. Bonanni and F. Couch and X. Wang and C. Vachon and Kristen S Purrington and G. Giles and R. Milne and C. McLean and C. Haiman and B. Henderson and F. Schumacher and L. Le Marchand and J. Simard and M. Goldberg and F. Labr{\`e}che and M. Dumont and S. Teo and C. Yip and Norhashimah Hassan and E. Vithana and V. Kristensen and W. Zheng and S. Deming-Halverson and M. Shrubsole and J. Long and R. Winqvist and K. Pylk{\"a}s and A. Jukkola-Vuorinen and S. Kauppila and I. Andrulis and J. Knight and G. Glendon and S. Tchatchou and P. Devilee and R. Tollenaar and C. Seynaeve and C. V. van Asperen and M. Garc{\'i}a-Closas and J. Figueroa and J. Lissowska and L. Brinton and K. Czene and H. Darabi and M. Eriksson and J. Brand and M. Hooning and A. Hollestelle and A. V. D. van den Ouweland and A. Jager and J. Li and J. Liu and K. Humphreys and X. Shu and W. Lu and Y. Gao and H. Cai and Simon S. Cross and M. Reed and W. Blot and L. Signorello and Qiuyin Cai and P. Pharoah and Barbara J. Perkins and M. Shah and F. Blows and D. Kang and K. Yoo and D. Noh and M. Hartman and Hui Miao and K. Chia and T. Putti and U. Hamann and C. Luccarini and C. Baynes and S. Ahmed and M. Maranian and C. Healey and A. Jakubowska and J. Lubiński and K. Jaworska-Bieniek and K. Durda and S. Sangrajrang and V. Gaborieau and P. Brennan and J. McKay and S. Slager and A. Toland and D. Yannoukakos and C. Shen and C. Hsiung and P. Wu and S. Ding and A. Ashworth and M. Jones and N. Orr and A. Swerdlow and H. Tsimiklis and E. Makalic and D. Schmidt and Q. M. Bui and S. Chanock and D. Hunter and R. Hein and N. Dahmen and L. Beckmann and K. Aaltonen and T. Muranen and T. Heikkinen and A. Irwanto and N. Rahman and C. Turnbull and Q. Waisfisz and H. Meijers-Heijboer and M. Adank and R. B. van der Luijt and P. Hall and G. Chenevix-Trench and A. Dunning and D. Easton and A. Cox},
  journal={Human molecular genetics},
  year={2015},
  volume={24 1},
  pages={
          285-98
        }
}
  • Wei-Yu Lin, N. Camp, +218 authors A. Cox
  • Published 2015
  • Biology, Medicine
  • Human molecular genetics
  • Previous studies have suggested that polymorphisms in CASP8 on chromosome 2 are associated with breast cancer risk. To clarify the role of CASP8 in breast cancer susceptibility, we carried out dense genotyping of this region in the Breast Cancer Association Consortium (BCAC). Single-nucleotide polymorphisms (SNPs) spanning a 1 Mb region around CASP8 were genotyped in 46 450 breast cancer cases and 42 600 controls of European origin from 41 studies participating in the BCAC as part of a custom… CONTINUE READING
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    References

    SHOWING 1-10 OF 22 REFERENCES
    Fine-Mapping CASP8 Risk Variants in Breast Cancer
    • 27
    • PDF
    Large-scale genotyping identifies 41 new loci associated with breast cancer risk
    • 918
    • PDF
    A breast cancer risk haplotype in the caspase-8 gene.
    • 28
    • PDF
    Association of a common variant of the CASP8 gene with reduced risk of breast cancer.
    • 155
    • PDF
    Genome-wide association study identifies five new breast cancer susceptibility loci
    • 652
    Genome-wide association study identifies three new melanoma susceptibility loci
    • 223
    • PDF
    Systematic identification of trans eQTLs as putative drivers of known disease associations
    • 1,331
    • PDF
    A common coding variant in CASP8 is associated with breast cancer risk
    • 561
    • PDF
    Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers.
    • 191
    • PDF
    Genome-wide Association Study Identifies Multiple Risk Loci for Chronic Lymphocytic Leukemia
    • 164
    • PDF