Identification and characterization of novel human glucose-6-phosphate dehydrogenase inhibitors.

@article{Preuss2013IdentificationAC,
  title={Identification and characterization of novel human glucose-6-phosphate dehydrogenase inhibitors.},
  author={Janina Preuss and Adam Richardson and Anthony B Pinkerton and Michael P. Hedrick and Eduard Sergienko and Stefan Rahlfs and Katja Becker and Lars Bode},
  journal={Journal of biomolecular screening},
  year={2013},
  volume={18 3},
  pages={286-97}
}
Glucose-6-phosphate dehydrogenase (G6PD) is the key enzyme of the pentose phosphate pathway, converting glucose-6-phosphate to 6-phosphoglucono-δ-lactone with parallel reduction of NADP(+). Several human diseases, including cancer, are associated with increased G6PD activity. To date, only a few G6PD inhibitors have been available. However, adverse side effects and high IC(50) values hamper their use as therapeutics and basic research probes. In this study, we developed a high-throughput… CONTINUE READING

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