Identification and characterization of new functional truncated variants of somatostatin receptor subtype 5 in rodents

@article{CrdobaChacn2009IdentificationAC,
  title={Identification and characterization of new functional truncated variants of somatostatin receptor subtype 5 in rodents},
  author={Jos{\'e} C{\'o}rdoba-Chac{\'o}n and Manuel D Gahete and Mario Duran-Prado and Ana I. Pozo-Salas and Mar{\'i}a Del Mar Malag{\'o}n and Francisco Gracia-Navarro and Rhonda D. Kineman and Ra{\'u}l M Luque and Justo P Casta{\~n}o},
  journal={Cellular and Molecular Life Sciences},
  year={2009},
  volume={67},
  pages={1147-1163}
}
Somatostatin and cortistatin exert multiple biological actions through five receptors (sst1-5); however, not all their effects can be explained by activation of sst1-5. Indeed, we recently identified novel truncated but functional human sst5-variants, present in normal and tumoral tissues. In this study, we identified and characterized three novel truncated sst5 variants in mice and one in rats displaying different numbers of transmembrane-domains [TMD; sst5TMD4, sst5TMD2, sst5TMD1 (mouse… CONTINUE READING
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