Identification and characterization of naturally occurring splice variants of SAMHD1

Abstract

Sterile Alpha Motif and HD domain-containing protein 1 (SAMHD1) is a recently identified host factor that restricts HIV-1 replication in dendritic and myeloid cells. SAMHD1 is a dNTPase that presumably reduces the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. However, HIV-2 and SIV encoded Vpx counteracts the… (More)
DOI: 10.1186/1742-4690-9-86

Topics

6 Figures and Tables