Identification and characterization of mutants with increased expression of hilA, the invasion gene transcriptional activator of Salmonella typhimurium.

@article{Fahlen2000IdentificationAC,
  title={Identification and characterization of mutants with increased expression of hilA, the invasion gene transcriptional activator of Salmonella typhimurium.},
  author={Thomas F. Fahlen and Neeta Mathur and Bradley D. Jones},
  journal={FEMS immunology and medical microbiology},
  year={2000},
  volume={28 1},
  pages={
          25-35
        }
}
Induction of invasion gene transcription and expression of the invasive phenotype of Salmonella strains are regulated by environmental conditions. Experimental evidence indicates that oxygen, pH, and osmotic conditions need to closely resemble those of the host intestinal lumen for invasion gene activation. The hilA gene, encoded on Salmonella pathogenicity island 1 (SPI-1), is a transcriptional activator which is required for invasion and whose expression is modulated by oxygen, pH, and… CONTINUE READING

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