Identification and characterization of multiple novel Rab–myosin Va interactions

  title={Identification and characterization of multiple novel Rab–myosin Va interactions},
  author={Andrew J. Lindsay and Florence Jollivet and Conor P. Horgan and Amir Riyaz Khan and Graça Raposo and Mary W. McCaffrey and Bruno Goud},
  booktitle={Molecular biology of the cell},
Myosin Va is a widely expressed actin-based motor protein that binds members of the Rab GTPase family (3A, 8A, 10, 11A, 27A) and is implicated in many intracellular trafficking processes. To our knowledge, myosin Va has not been tested in a systematic screen for interactions with the entire Rab GTPase family. To that end, we report a yeast two-hybrid screen of all human Rabs for myosin Va-binding ability and reveal 10 novel interactions (3B, 3C, 3D, 6A, 6A', 6B, 11B, 14, 25, 39B), which include… CONTINUE READING