Identification and characterization of human UDP-glucuronosyltransferases responsible for the in vitro glucuronidation of daphnetin.

@article{Liang2010IdentificationAC,
  title={Identification and characterization of human UDP-glucuronosyltransferases responsible for the in vitro glucuronidation of daphnetin.},
  author={Si-cheng Liang and Guang-Bo Ge and H. Liu and Yan-yan Zhang and Li-Ming Wang and Jiang-wei Zhang and Lu Jian Yin and Wei Li and Zhong-Ze Fang and Jing-Jing Wu and Guo-Hui Li and Ling Yang},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2010},
  volume={38 6},
  pages={
          973-80
        }
}
Daphnetin has been developed as an oral medicine for treatment of coagulation disorders and rheumatoid arthritis in China, but its in vitro metabolism remains unknown. In the present study, the UDP-glucuronosyltransferase (UGT) conjugation pathways of daphnetin were characterized. Two metabolites, 7-O-monoglucuronide daphnetin (M-1) and 8-O-monoglucuronide daphnetin (M-2), were identified by liquid chromatography/mass spectrometry and NMR when daphnetin was incubated, respectively, with liver… CONTINUE READING

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