Identification and characterization of genes susceptible to transcriptional cross-talk between the hypoxia and dioxin signaling cascades.

@article{Lee2006IdentificationAC,
  title={Identification and characterization of genes susceptible to transcriptional cross-talk between the hypoxia and dioxin signaling cascades.},
  author={Kangae Lee and L. D. Burgoon and Laura E. Lamb and E. Dere and Timothy R. Zacharewski and John B. Hogenesch and John J Lapres},
  journal={Chemical research in toxicology},
  year={2006},
  volume={19 10},
  pages={1284-93}
}
The aryl hydrocarbon receptor (AHR) and hypoxia inducible factors (HIFs) are transcription factors that control the adaptive response to toxicants such as dioxins and decreases in available oxygen, respectively. The AHR and HIFs utilize the same heterodimeric partner, the aryl hydrocarbon nuclear translocator (ARNT) for proper function. This requirement raises the possibility that cross-talk exists between these critical signaling systems. Single gene and reporter assays have yielded… CONTINUE READING
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