Identification and characterization of gangliosides reacting with IgM paraproteins in three patients with neuropathy associated with biclonal gammopathy.

@article{Ilyas1988IdentificationAC,
  title={Identification and characterization of gangliosides reacting with IgM paraproteins in three patients with neuropathy associated with biclonal gammopathy.},
  author={Amjad A Ilyas and Hugh John Willison and Marinos C. Dalakas and John N. Whitaker and Richard H. Quarles},
  journal={Journal of neurochemistry},
  year={1988},
  volume={51 3},
  pages={851-8}
}
IgM monoclonal antibodies from three patients with polyneuropathy associated with biclonal gammopathy reacted with monosialoganglioside GM1 on thin-layer chromatograms. An IgM paraprotein in one of the patients with a predominantly motor neuropathy also reacted strongly with the ganglioside GD1b and asialo-GM1. All three of these antigenic lipids have a Gal(beta 1-3)GalNAc moiety in common which would appear to be the antigenic determinant. However, this IgM also cross-reacted weakly with… CONTINUE READING