Identification and characterization of gamma-glutamylamine cyclotransferase, an enzyme responsible for gamma-glutamyl-epsilon-lysine catabolism.

Abstract

Gamma-glutamylamine cyclotransferase (GGACT) is an enzyme that converts gamma-glutamylamines to free amines and 5-oxoproline. GGACT shows high activity toward gamma-glutamyl-epsilon-lysine, derived from the breakdown of fibrin and other proteins cross-linked by transglutaminases. The enzyme adopts the newly identified cyclotransferase fold, observed in… (More)
DOI: 10.1074/jbc.M109.082099

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@article{Oakley2010IdentificationAC, title={Identification and characterization of gamma-glutamylamine cyclotransferase, an enzyme responsible for gamma-glutamyl-epsilon-lysine catabolism.}, author={Aaron J. Oakley and Marjorie Coggan and Philip G Board}, journal={The Journal of biological chemistry}, year={2010}, volume={285 13}, pages={9642-8} }