Identification and characterization of functional domains in a mixed lineage kinase LZK

@article{Ikeda2001IdentificationAC,
  title={Identification and characterization of functional domains in a mixed lineage kinase LZK},
  author={Atsushi Ikeda and Megumi Masaki and Yasunori Kozutsumi and Shogo Oka and Toshisuke Kawasaki},
  journal={FEBS Letters},
  year={2001},
  volume={488}
}
Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically.
TLDR
A molecule localized to mitochondria, antioxidant protein-1 (AOP-1), that binds to LZK and which acts as a modulator of LZk activity is identified by means of a yeast two-hybrid screening system.
Mixed lineage kinases (MLKs): a role in dendritic cells, inflammation and immunity?
TLDR
Current knowledge about the mixed lineage kinases is summarized and it is suggested that MLKs are not only expressed in cells of the immune system (as well as in the nervous system), but also may be implicated selectively in the signalling pathway that follows on toll‐like receptor ligation in innate sentinel cells, such as the dendritic cell.
Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons
TLDR
The data support the possibility for two structurally related MAP3Ks to work in concert to mediate axonal responses to external insult or injury in mammalian CNS neurons.
Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength
TLDR
Investigation of MAP3K Dual leucine zipper kinases in cerebellar Purkinje cells using loss- and gain-of function mouse models finds deleting CELF2, which regulates alternative splicing of Mkk7, strongly attenuatesPurkinje cell degeneration induced by activation of LZK, but not DLK.
Mitogen-activated protein kinases in dendritic cell maturation and death
TLDR
It is suggested that excessive DC maturation, which may induce pathogenic T cell activation may be limited by DC apoptosis, and the mechanisms leading to MAPK activation upon TLR ligation are explored.
POSH is an Intracellular Signal Transducer for the Axon Outgrowth Inhibitor Nogo66
TLDR
An intracellular signaling pathway for process outgrowth inhibition by Nogo66 is delineated, comprised of NogoA, PirB, POSH, LZK, and Shroom3, and implicate the POSH complex as a potential therapeutic target to enhance axon outgrowth and plasticity in the injured CNS.
RNA Interference Screen to Identify Kinases That Suppress Rescue of (cid:2) F508-CFTR* □ S
TLDR
The role of FGFR signaling on ( cid:2) F508-CFTR trafficking was further elucidated by knocking down FGFRs and their downstream signaling proteins: Erk1/2, Akt, PLC (cid:3) -1, and FRS2.
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TLDR
The expression of ZAK in mammalian cells specifically leads to the activation of the JNK/SAPK pathway as well as theactivation of transcription factor, NF-kappaB, which induces the apoptosis of a hepatoma cell line.
MST/MLK2, a Member of the Mixed Lineage Kinase Family, Directly Phosphorylates and Activates SEK1, an Activator of c-Jun N-terminal Kinase/Stress-activated Protein Kinase*
TLDR
Results suggest that MLK family members are MAPK kinase kinases preferentially acting on the JNK/SAPK pathway.
Molecular Cloning and Functional Expression of a cDNA Encoding a New Member of Mixed Lineage Protein Kinase from Human Brain*
TLDR
Northern blot analysis revealed that LZK is expressed most strongly in the pancreas, with a pattern that differs from other MLKs, suggesting that L ZK interacts with other cellular components in vivo.
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TLDR
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TLDR
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TLDR
The biochemistry and regulation of dual leucine zipper bearing kinase (DLK), a member of the mixed lineage kinase or MLK subfamily of protein kinases, was examined in the nervous system and it was concluded that DLK formed covalently associated homodimers in overexpressing COS 7 cells.
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