Identification and characterization of functional domains in a mixed lineage kinase LZK

@article{Ikeda2001IdentificationAC,
  title={Identification and characterization of functional domains in a mixed lineage kinase LZK},
  author={Atsushi Ikeda and Megumi Masaki and Yasunori Kozutsumi and Shogo Oka and Toshisuke Kawasaki},
  journal={FEBS Letters},
  year={2001},
  volume={488}
}
Effect of C-terminal truncations on MLK7 catalytic activity and JNK activation.
Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically.
TLDR
A molecule localized to mitochondria, antioxidant protein-1 (AOP-1), that binds to LZK and which acts as a modulator of LZk activity is identified by means of a yeast two-hybrid screening system.
Mixed lineage kinases (MLKs): a role in dendritic cells, inflammation and immunity?
TLDR
Current knowledge about the mixed lineage kinases is summarized and it is suggested that MLKs are not only expressed in cells of the immune system (as well as in the nervous system), but also may be implicated selectively in the signalling pathway that follows on toll‐like receptor ligation in innate sentinel cells, such as the dendritic cell.
Signalling: Mixed-lineage kinase control of JNK and p38 MAPK pathways
TLDR
Mixed-lineage kinases are serine/threonine protein kinases that regulate signalling by the c-Jun amino-terminal kinase (JNK) and p38 mitogen-activated-protein kinases (MAPK) pathways and are potential drug targets for many neurodegenerative diseases.
Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons
TLDR
The data support the possibility for two structurally related MAP3Ks to work in concert to mediate axonal responses to external insult or injury in mammalian CNS neurons.
Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength
TLDR
Investigation of MAP3K Dual leucine zipper kinases in cerebellar Purkinje cells using loss- and gain-of function mouse models finds deleting CELF2, which regulates alternative splicing of Mkk7, strongly attenuatesPurkinje cell degeneration induced by activation of LZK, but not DLK.
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TLDR
The expression of ZAK in mammalian cells specifically leads to the activation of the JNK/SAPK pathway as well as theactivation of transcription factor, NF-kappaB, which induces the apoptosis of a hepatoma cell line.
MST/MLK2, a Member of the Mixed Lineage Kinase Family, Directly Phosphorylates and Activates SEK1, an Activator of c-Jun N-terminal Kinase/Stress-activated Protein Kinase*
TLDR
Results suggest that MLK family members are MAPK kinase kinases preferentially acting on the JNK/SAPK pathway.
The Mixed Lineage Kinase SPRK Phosphorylates and Activates the Stress-activated Protein Kinase Activator, SEK-1*
TLDR
It is reported herein that SPRK activates the stress-activated protein kinases (SAPKs) but not ERK-1 during transient expression in COS cells; the p38 kinase is activated modestly but consistently; and Immunoprecipitated recombinant SPRK is able to phosphorylate and activate recombinant SEK- 1 in vitro to an extent comparable to that achieved by MEK kinase-1.
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TLDR
Northern blot analysis revealed that LZK is expressed most strongly in the pancreas, with a pattern that differs from other MLKs, suggesting that L ZK interacts with other cellular components in vivo.
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TLDR
A novel protein kinase is identified from human thymus using RT-PCR and cDNA library screening and shows homology with the mixed-lineage family of protein kinases (MLK) and shares the unusual leucine zipper-basic motif found in previously identified MLK kinases.
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TLDR
The predicted MLK2 polypeptide has 954 amino acids and contains a src homology 3 (SH3) domain, a kinase catalyticdomain, a double leucine zipper and basic domain, and a large C-terminal domain, which has a biased ratio of basic to acidic amino acids.
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TLDR
Results suggest that DLK lies distal to Rac1 and/or Cdc42Hs but proximal to MEKK1 in a pathway leading from v-Src to SAPKs activation.
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TLDR
Using the polymerase chain reaction to study mRNA expressed in human epithelial tumor cells, a member of a new family of protein kinases was identified that has amino-acid-sequence similarity to both the Tyr-specific and the Ser/Thr-specific kinase classes.
Identification of Structural and Functional Domains in Mixed Lineage Kinase Dual Leucine Zipper-bearing Kinase Required for Complex Formation and Stress-activated Protein Kinase Activation*
TLDR
Analysis of structure-function analysis of mixed lineage kinase dual leucine zipper-bearing kinase domains provides evidence that protein complex formation is required for signal transduction from DLK to SAPK.
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