Identification and characterization of estrogen receptor variants in prostate cancer cell lines.

@article{Ye2000IdentificationAC,
  title={Identification and characterization of estrogen receptor variants in prostate cancer cell lines.},
  author={Qinong Ye and Lo Woei Chung and Bekir Cinar and Su-xia Li and Haiyen E. Zhau},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2000},
  volume={75 1},
  pages={21-31}
}
A sensitive semi-nested reverse transcriptase-polymerase chain reaction (RT-PCR) amplification was performed to evaluate estrogen receptor-alpha (ER-alpha) mRNA expression in prostate cancer cell lines. We demonstrated the presence of wild-type ER-alpha (wt ER-alpha) and five ER-alpha variants, designated ER-alphaA, B, C, D, and E. Unlike ER-alphaA and D, ER-alphaB, C, and E were not previously reported in normal or cancerous mammalian cells. DNA sequencing analysis of these ER-alpha variants… CONTINUE READING

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