Identification and characterization of endogenous viral elements for the three key schistosomes of humans.

  • Na Li, Quhuan Li
  • Published 2015 in Pakistan journal of pharmaceutical sciences

Abstract

Endogenous viral elements (EVEs) are widely distributed throughout eukaryotic genomes, and their evolution and potential function have attracted a lot of interest. Draft genome sequences for Schistosoma mansoni, Schistosoma japonicum and Schistosoma haematobium are now available; however, information about EVEs in blood flukes of the genus schistosoma is scanty. Here, genome-wide survey into the putative EVE sequences of the three key schistosome genomes were present. Totally 4, 117 gene sequences were identified, including retrovirus-like gypsy elements, RNA viruses and dsDNA viruses. Compared with S. japonicum and S. haematobium, S. mansoni appeared to greatly out numbered by gypsy members. Phylogenetic analysis revealed one novel endogenous retrovirus element in S. mansoni. This initial characterization of schistosomes showed that schistosomes harbour distinct EVEs that may have played an important evolutionary role. Studies of schistosomes' endogenous viruses helped us to glance at an earlier viral event in the class Trematoda, greatly broadening the field of palaeovirology.

Cite this paper

@article{Li2015IdentificationAC, title={Identification and characterization of endogenous viral elements for the three key schistosomes of humans.}, author={Na Li and Quhuan Li}, journal={Pakistan journal of pharmaceutical sciences}, year={2015}, volume={28 1 Suppl}, pages={375-82} }