Identification and characterization of curcuminoids in turmeric using ultra-high performance liquid chromatography-quadrupole time of flight tandem mass spectrometry.

@article{Jia2017IdentificationAC,
  title={Identification and characterization of curcuminoids in turmeric using ultra-high performance liquid chromatography-quadrupole time of flight tandem mass spectrometry.},
  author={Shuailong Jia and Zhifeng Du and Chengwu Song and Shuna Jin and Yang Zhang and Yulin Feng and Chao-mei Xiong and Hongliang Jiang},
  journal={Journal of chromatography. A},
  year={2017},
  volume={1521},
  pages={
          110-122
        }
}
A three-step strategy was developed for systematic characterization of curcuminoids in turmeric. Based on UHPLC-QTOF-MS/MS analysis, 89 curcuminoids including 16 novel ones were identified in the turmeric samples using this approach. During the identification process, false positive results were excluded by combining the positive and negative ESI-MS/MS analyses. Moreover, the characterization of the keto and enol forms of type A, B and C curcuminoids was first discussed and they were clearly… Expand
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References

SHOWING 1-10 OF 31 REFERENCES
Use of liquid chromatography-electrospray ionization tandem mass spectrometry to identify diarylheptanoids in turmeric (Curcuma longa L.) rhizome.
TLDR
LC-ESI-MS/MS coupled to DAD analysis was used as an on-line tool for identification of diarylheptanoids in fresh turmeric rhizome extracts and 19 diaryl heptanoid compounds were identified, 12 of which have not been previously reported from turmeric and six are new compounds. Expand
An integrated strategy for establishment of curcuminoid profile in turmeric using two LC–MS/MS platforms
TLDR
The structural identification procedures of curcuminoids and the integrated strategy provide a suitable method to analyze targeted plant metabolites which occur in a high number but sharing either structural similarities or similar functional groups. Expand
Direct analysis of curcumin in turmeric by DART-MS.
TLDR
A pilot study using the well-known antioxidant botanical drug, turmeric, shows that DART-MS can be applied for semi-quantitative determinations of curcumin over a large range (5-100 microg/mL). Expand
Analysis of curcuminoids by positive and negative electrospray ionization and tandem mass spectrometry.
TLDR
These experiments yielded essentially the same fragmentation results in both ion trap and ICR instruments for all three curcuminoids and for their phenolic monoacetates. Expand
Characterization and identification of steroidal saponins from the seeds of Trigonella foenum-graecum by ultra high-performance liquid chromatography and hybrid time-of-flight mass spectrometry.
  • L. Kang, Yang Zhao, +7 authors B. Ma
  • Chemistry, Medicine
  • Journal of pharmaceutical and biomedical analysis
  • 2013
TLDR
Low-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry was used to rapidly separate and identify steroidal saponins from the crude extract of the seeds of Trigonella foenum-graecum (TFG). Expand
Analysis of phytochemical variations in dioecious Tinospora cordifolia stems using HPLC/QTOF MS/MS and UPLC/QqQLIT -MS/MS.
TLDR
Phytochemicals in the stem of male and female Tinospora cordifolia showed significant qualitative and quantitative variations and LC-MS and MS/MS methods can be used to differentiate between male andFemale plants based on their chemical profiles and quantities of the marker bioactive alkaloids. Expand
Fragmentation study on the phenolic alkaloid neferine and its analogues with anti-HIV activities by electrospray ionization tandem mass spectrometry with hydrogen/deuterium exchange and its application for rapid identification of in vitro microsomal metabolites of neferine.
TLDR
The results suggest that N-dem methylation and O-demethylation are two important metabolic pathways of neferine in dog hepatic microsomal incubations, critical for screening and development of phenolic bisbenzyltetrahydroisoquinoline alkaloids with anti-HIV activities such as neferines and its analogues isoliensinine and liensinine. Expand
Identification of antitumor constituents in curcuminoids from Curcuma longa L. based on the composition-activity relationship.
TLDR
13 of the curcuminoids were significantly correlated with antitumor activity via a Loadings plot and VIP in OPLS and a correlation coefficient in CCA, which support a method for the discovery of antitumors active constituents. Expand
Curcuminoid’s Content and Fingerprint Analysis for Authentication and Discrimination of Curcuma xanthorrhiza from Curcuma longa by High-Performance Liquid Chromatography-Diode Array Detector
An accurate and reliable method for authentication and discrimination of Curcuma xanthorrhiza (CX) from Curcuma longa (CL) by determining the curcuminoid’s content and analyzing the HPLC fingerprintExpand
Secondary Metabolite Profiling of Curcuma Species Grown at Different Locations Using GC/TOF and UPLC/Q-TOF MS
TLDR
A combination of GC- and LC-MS allowed us to analyze curcuminoids and terpenoids, the typical bioactive compounds of Curcuma, which can be used to discriminate CurCuma samples according to species or geographical origin. Expand
...
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