Corpus ID: 19099273

Identification and characterization of Saccharomyces cerevisiae EXO 1 , a gene encoding an exonuclease that interacts with MSH 2

@inproceedings{Tishkoff1997IdentificationAC,
  title={Identification and characterization of Saccharomyces cerevisiae EXO 1 , a gene encoding an exonuclease that interacts with MSH 2},
  author={D. Tishkoff and A. Boerger and P. Bertrand and N. Filosi and G. M. Gaida and M. Kane and R. Kolodner},
  year={1997}
}
  • D. Tishkoff, A. Boerger, +4 authors R. Kolodner
  • Published 1997
  • A two-hybrid screen was used to identify Saccharomyces cerevisiae genes encoding proteins that interact with MSH2. One gene was found to encode a homologue of Schizosaccharomyces pombe EXO1, a double-stranded DNA-specific 5*–3* exonuclease. S. cerevisiae EXO1 interacted with both S. cerevisiae and human MSH2 in two-hybrid and coimmunoprecipitation experiments. exo1 mutants showed a mutator phenotype, and epistasis analysis was consistent with EXO1 functioning in the MSH2-dependent mismatch… CONTINUE READING
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