Identification and characterization of osteoclast-like cells and their progenitors in cultures of feline marrow mononuclear cells

@article{Ibbotson1984IdentificationAC,
  title={Identification and characterization of osteoclast-like cells and their progenitors in cultures of feline marrow mononuclear cells},
  author={K. J. Ibbotson and Garson David Roodman and Linda M. McManus and Gregory R. Mundy},
  journal={The Journal of Cell Biology},
  year={1984},
  volume={99},
  pages={471 - 480}
}
The predominant cell responsible for bone resorption, the multinucleated osteoclast, has been difficult to study because of inaccessibility. When feline marrow-derived mononuclear cells are established in long-term culture, multinucleated cells form within 48 h, reaching maximum numbers at 16 d. We have observed that these cultured cells have many of the features of osteoclasts. Morphologically, they are multinucleated, contain large numbers of branched mitochondria, have a peripheral cytoplasm… CONTINUE READING

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